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Target
Type-2 angiotensin II receptor
Ligand
BDBM50283170
Substrate
n/a
Meas. Tech.
ChEBML_35563
IC50
90±n/a nM
Citation
 Olson, RE; Liu, J; Lalka, GK; VanAtten, MK; Wexler, RR; Chiu, AT; Nguyen, TT; McCall, DE; Wong, PC; Timmermans, PB Balanced angiotensin II receptor antagonists. II.1,2 4-aminomethyl- and acylaminomethylimidazoles Bioorg Med Chem Lett 4:2229-2234 (1994)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50283170
Synonyms:
1-[4-(2-pentanyloxycarbonylsulfamoylphenyl)benzyl]-2-propyl-4-[4-(2-pyridyl)hexahydro-1-pyrazinylmethyl]-1H-5-imidazolecarboxylic acid | CHEMBL308361
Type:
Small organic molecule
Emp. Form.:
C35H42N6O6S
Mol. Mass.:
674.81
SMILES:
CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(CC3)c3ccccn3)c2C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: