Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50284847
Substrate
n/a
Meas. Tech.
ChEBML_54063
Ki
>500±n/a nM
Citation
 Batt, DG; Copeland, RA; Dowling, RL; Gardner, TL; Jones, EA; Orwat, MJ; Pinto, DJ; Pitts, WJ; Magolda, RL; Jaffee, BD Immunosuppressive structure-activity relationships of Brequinar and related cinchoninic acid derivatives Bioorg Med Chem Lett 5:1549-1554 (1995)    Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50284847
Synonyms:
5-Biphenyl-4-yl-3-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid | CHEMBL288852
Type:
Small organic molecule
Emp. Form.:
C20H15N3O2
Mol. Mass.:
329.352
SMILES:
Cn1cnc2c(cc(nc12)-c1ccc(cc1)-c1ccccc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: