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Target
Neprilysin
Ligand
BDBM50285325
Substrate
n/a
Meas. Tech.
ChEBML_144602
IC50
32±n/a nM
Citation
 Lombaert, SD; Blanchard, L; Tan, J; Sakane, Y; Berry, C; Ghai, RD Non-peptidic inhibitors of neutral endopeptidase 24.11 1. Discovery and optimization of potency Bioorg Med Chem Lett 5:145-150 (1995)    Article 
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11
Type:
Protein
Mol. Mass.:
85789.59
Organism:
Rattus norvegicus (Rat)
Description:
P07861
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
  
Inhibitor
Name:
BDBM50285325
Synonyms:
(E)-(S)-5-Biphenyl-4-yl-4-(phosphonomethyl-amino)-pent-2-enoic acid | CHEMBL37117
Type:
Small organic molecule
Emp. Form.:
C18H20NO5P
Mol. Mass.:
361.3289
SMILES:
OC(=O)C=C[C@H](Cc1ccc(cc1)-c1ccccc1)NCP(O)(O)=O |w:3.2|
Structure:
Search PDB for entries with ligand similarity: