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Target
Substance-P receptor
Ligand
BDBM50287337
Substrate
n/a
Meas. Tech.
ChEBML_142882
IC50
10±n/a nM
Citation
 Teall, M; Harrison, T; Moseley, JD; Owens, AP; Sadowski, S; Cascieri, MA Linear amides as substance P antagonists Bioorg Med Chem Lett 6:1585-1588 (1996)    Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50287337
Synonyms:
CHEMBL291025 | N-[2-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-N-methyl-3,3-diphenyl-propionamide
Type:
Small organic molecule
Emp. Form.:
C26H23F6NO
Mol. Mass.:
479.4573
SMILES:
CN(CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)CC(c1ccccc1)c1ccccc1
Structure:
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