Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50292884
Substrate
n/a
Meas. Tech.
ChEMBL_494607 (CHEMBL945266)
Ki
2500±n/a nM
Citation
 de Candia, M; Liantonio, F; Carotti, A; De Cristofaro, R; Altomare, C Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation. J Med Chem 52:1018-28 (2009) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50292884
Synonyms:
CHEMBL523099 | N-(3-(biphenyl-4-ylmethoxy)phenyl)piperidine-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H26N2O2
Mol. Mass.:
386.4861
SMILES:
O=C(Nc1cccc(OCc2ccc(cc2)-c2ccccc2)c1)C1CCCNC1
Structure:
Search PDB for entries with ligand similarity: