Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50292894
Substrate
n/a
Meas. Tech.
ChEMBL_494607 (CHEMBL945266)
Ki
512±n/a nM
Citation
 de Candia, M; Liantonio, F; Carotti, A; De Cristofaro, R; Altomare, C Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation. J Med Chem 52:1018-28 (2009) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50292894
Synonyms:
CHEMBL490491 | N-(3-((2',4'-difluorobiphenyl-4-yl)methoxy)phenyl)piperidine-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H24F2N2O2
Mol. Mass.:
422.4671
SMILES:
Fc1ccc(c(F)c1)-c1ccc(COc2cccc(NC(=O)C3CCNCC3)c2)cc1
Structure:
Search PDB for entries with ligand similarity: