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Target
Acyl-CoA desaturase 1
Ligand
BDBM50304956
Substrate
n/a
Meas. Tech.
ChEMBL_606657 (CHEMBL1071884)
IC50
7±n/a nM
Citation
 Uto, Y; Ogata, T; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Deguchi, T; Watanabe, N; Konishi, M; Okuyama, R; Kurikawa, N; Takagi, T; Wakimoto, S; Ohsumi, J Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats. Bioorg Med Chem Lett 20:341-5 (2010) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50304956
Synonyms:
CHEMBL592754 | N-(2-hydroxy-2-(thiophen-2-yl)ethyl)-6-(4-(2-methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C24H26N4O3S
Mol. Mass.:
450.553
SMILES:
Cc1ccccc1C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NCC(O)c1cccs1
Structure:
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