Reaction Details Report a problem with these data
Target
Stearoyl-CoA desaturase
Ligand
BDBM50304942
Substrate
n/a
Meas. Tech.
ChEMBL_606658 (CHEMBL1071885)
IC50
90±n/a nM
Citation
Uto, Y; Ogata, T; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Deguchi, T; Watanabe, N; Konishi, M; Okuyama, R; Kurikawa, N; Takagi, T; Wakimoto, S; Ohsumi, J Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats. Bioorg Med Chem Lett 20:341-5 (2010) [PubMed] Article
More Info.:
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
Inhibitor
Name:
BDBM50304942
Synonyms:
(S)-N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)pyridazine-3-carboxamide | CHEMBL602933
Type:
Small organic molecule
Emp. Form.:
C25H24F3N5O3
Mol. Mass.:
499.485
SMILES:
O[C@H](CNC(=O)c1ccc(nn1)N1CCN(CC1)C(=O)c1ccccc1C(F)(F)F)c1ccccc1 |r|