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Target
Aurora kinase B
Ligand
BDBM50197834
Substrate
n/a
Meas. Tech.
ChEMBL_609005 (CHEMBL1073147)
IC50
2140±n/a nM
Citation
 Hegde, VR; Borges, S; Patel, M; Das, PR; Wu, B; Gullo, VP; Chan, TM New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. Bioorg Med Chem Lett 20:1344-6 (2010) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50197834
Synonyms:
2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-one | CHEMBL388956 | SCH-546909 | aristolactam AIIIa | aristololactam A IIIa
Type:
Small organic molecule
Emp. Form.:
C16H11NO4
Mol. Mass.:
281.2628
SMILES:
COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23
Structure:
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