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Target
Cyclin-dependent kinase 4
Ligand
BDBM50197834
Substrate
n/a
Meas. Tech.
ChEMBL_609004 (CHEMBL1073146)
IC50
1420±n/a nM
Citation
 Hegde, VR; Borges, S; Patel, M; Das, PR; Wu, B; Gullo, VP; Chan, TM New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. Bioorg Med Chem Lett 20:1344-6 (2010) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50197834
Synonyms:
2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-one | CHEMBL388956 | SCH-546909 | aristolactam AIIIa | aristololactam A IIIa
Type:
Small organic molecule
Emp. Form.:
C16H11NO4
Mol. Mass.:
281.2628
SMILES:
COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23
Structure:
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