Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50310902
Substrate
n/a
Meas. Tech.
ChEMBL_622829 (CHEMBL1105839)
IC50
55±n/a nM
Citation
 Bedford, ST; Benwell, KR; Brooks, T; Chen, I; Comer, M; Dugdale, S; Haymes, T; Jordan, AM; Kennett, GA; Knight, AR; Klenke, B; LeStrat, L; Merrett, A; Misra, A; Lightowler, S; Padfield, A; Poullennec, K; Reece, M; Simmonite, H; Wong, M; Yule, IA Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor. Bioorg Med Chem Lett 19:5945-9 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50310902
Synonyms:
(5-methylthiophen-2-yl)(2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone | CHEMBL1078349
Type:
Small organic molecule
Emp. Form.:
C18H14N4OS2
Mol. Mass.:
366.46
SMILES:
Cc1ccc(s1)C(=O)c1nc(NCc2cccnc2)nc2ccsc12
Structure:
Search PDB for entries with ligand similarity: