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Target
Mitogen-activated protein kinase 11
Ligand
BDBM50315127
Substrate
n/a
Meas. Tech.
ChEMBL_624924 (CHEMBL1107047)
IC50
404±n/a nM
Citation
 Walker, JK; Selness, SR; Devraj, RV; Hepperle, ME; Naing, W; Shieh, H; Kurambail, R; Yang, S; Flynn, DL; Benson, AG; Messing, DM; Dice, T; Kim, T; Lindmark, RJ; Monahan, JB; Portanova, J Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett 20:2634-8 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41351.73
Organism:
Homo sapiens (Human)
Description:
gi_20128774
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
  
Inhibitor
Name:
BDBM50315127
Synonyms:
4-(3-(4-fluorophenyl)-5-(piperidin-3-yl)-1H-pyrazol-4-yl)pyridine | CHEMBL1091552
Type:
Small organic molecule
Emp. Form.:
C19H19FN4
Mol. Mass.:
322.3794
SMILES:
Fc1ccc(cc1)-c1n[nH]c(C2CCCNC2)c1-c1ccncc1
Structure:
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