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Target
Toll-like receptor 2
Ligand
BDBM50315417
Substrate
n/a
Meas. Tech.
ChEMBL_626546 (CHEMBL1108919)
IC50
1200±n/a nM
Citation
 Wu, W; Li, R; Malladi, SS; Warshakoon, HJ; Kimbrell, MR; Amolins, MW; Ukani, R; Datta, A; David, SA Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides. J Med Chem 53:3198-213 (2010) [PubMed]  Article 
Target
Name:
Toll-like receptor 2
Synonyms:
TIL4 | TLR2 | TLR2_HUMAN | Toll-like receptor 2 | Toll-like receptor 2 (TLR2)
Type:
Protein
Mol. Mass.:
89837.58
Organism:
Homo sapiens (Human)
Description:
O60603
Residue:
784
Sequence:
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
  
Inhibitor
Name:
BDBM50315417
Synonyms:
((R)-3-(2-((R)-2-Amino-3-hydroxypropanamido)ethylthio)propane-1,2-diyl Dipalmitate) | CHEMBL1092428
Type:
Small organic molecule
Emp. Form.:
C40H78N2O6S
Mol. Mass.:
715.122
SMILES:
CCCCCCCCCCCCCCCC(=O)OC[C@H](CSCCNC(=O)[C@H](N)CO)OC(=O)CCCCCCCCCCCCCCC |r|
Structure:
Search PDB for entries with ligand similarity: