Reaction Details Report a problem with these data
Target
Aurora kinase A
Ligand
BDBM50322816
Substrate
n/a
Meas. Tech.
ChEMBL_642509 (CHEMBL1175882)
IC50
43±n/a nM
Citation
 Coumar, MS; Chu, CY; Lin, CW; Shiao, HY; Ho, YL; Reddy, R; Lin, WH; Chen, CH; Peng, YH; Leou, JS; Lien, TW; Huang, CT; Fang, MY; Wu, SH; Wu, JS; Chittimalla, SK; Song, JS; Hsu, JT; Wu, SY; Liao, CC; Chao, YS; Hsieh, HP Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification. J Med Chem 53:4980-8 (2010) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50322816
Synonyms:
1-{4-[2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)ethyl]-phenyl}-3-phenylurea | CHEMBL1173731
Type:
Small organic molecule
Emp. Form.:
C33H27N5O2
Mol. Mass.:
525.5998
SMILES:
O=C(Nc1ccccc1)Nc1ccc(CCNc2ncnc3oc(c(-c4ccccc4)c23)-c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: