Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50324096
Substrate
n/a
Meas. Tech.
ChEMBL_649647 (CHEMBL1219345)
Ki
9.1±n/a nM
Citation
 Moussa, IA; Banister, SD; Beinat, C; Giboureau, N; Reynolds, AJ; Kassiou, M Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands. J Med Chem 53:6228-39 (2010) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50324096
Synonyms:
CHEMBL1215038 | N-(Benzofuran-2-ylmethyl)-N'-(2'-(3''-fluoropropoxy)benzyl)-piperazine
Type:
Small organic molecule
Emp. Form.:
C23H27FN2O2
Mol. Mass.:
382.4711
SMILES:
FCCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1
Structure:
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