Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 3
Ligand
BDBM50325913
Substrate
n/a
Meas. Tech.
ChEMBL_652723 (CHEMBL1225926)
IC50
33000±n/a nM
Citation
 Peters, JU; Kühne, H; Dehmlow, H; Grether, U; Conte, A; Hainzl, D; Hertel, C; Kratochwil, NA; Otteneder, M; Narquizian, R; Panousis, CG; Ricklin, F; Röver, S Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett 20:5426-30 (2010) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 3
Synonyms:
G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44498.06
Organism:
Homo sapiens (Human)
Description:
GPR109B 0 HUMAN::P49019
Residue:
387
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
  
Inhibitor
Name:
BDBM50325913
Synonyms:
2-(3-(2-chlorophenoxy)propoxy)pyrido[2,3-d]pyrimidin-4(3H)-one | CHEMBL1224070
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O3
Mol. Mass.:
331.754
SMILES:
Clc1ccccc1OCCCOc1nc2ncccc2c(=O)[nH]1
Structure:
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