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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM24796
Substrate
n/a
Meas. Tech.
ChEMBL_657596 (CHEMBL1247197)
IC50
4950±n/a nM
Citation
 John, S; Thangapandian, S; Sakkiah, S; Lee, KW Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies. Eur J Med Chem 45:4004-12 (2010) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM24796
Synonyms:
(11S,13S)-14,14-dimethyl-12,15-dioxatetracyclo[8.5.0.0^{3,8}.0^{11,13}]pentadeca-1(10),3(8),4,6-tetraene-2,9-dione | Pyranonaphthoquinone derivative, 33
Type:
Small organic molecule
Emp. Form.:
C15H12O4
Mol. Mass.:
256.2534
SMILES:
CC1(C)OC2=C([C@@H]3O[C@H]13)C(=O)c1ccccc1C2=O |r,c:4|
Structure:
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