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Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50332181
Substrate
n/a
Meas. Tech.
ChEMBL_687953 (CHEMBL1291625)
IC50
20000±n/a nM
Citation
 Nolan, KA; Caraher, MC; Humphries, MP; Bettley, HA; Bryce, RA; Stratford, IJ In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett 20:7331-6 (2010) [PubMed]  Article 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Human
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50332181
Synonyms:
2-(4-Methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile | CHEMBL1288165 | NSC-332172
Type:
Small organic molecule
Emp. Form.:
C19H19NO4
Mol. Mass.:
325.3585
SMILES:
COc1ccc(cc1)C(=C/c1cc(OC)c(OC)c(OC)c1)\C#N
Structure:
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