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Target
Type-1 angiotensin II receptor
Ligand
BDBM50282383
Substrate
n/a
Meas. Tech.
ChEMBL_717439 (CHEMBL1670338)
IC50
0.7±n/a nM
Citation
 Naik, P; Murumkar, P; Giridhar, R; Yadav, MR Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorg Med Chem 18:8418-56 (2010) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50282383
Synonyms:
2-Ethyl-5,7-dimethyl-3-[2'-(2-oxo-2,3-dihydro-2lambda*4*-[1,2,3,5]oxathiadiazol-4-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine | CHEMBL344407
Type:
Small organic molecule
Emp. Form.:
C24H23N5O2S
Mol. Mass.:
445.537
SMILES:
CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1C1=NS(=O)ON1 |t:30|
Structure:
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