Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50281848
Substrate
n/a
Meas. Tech.
ChEMBL_717466 (CHEMBL1670671)
IC50
2.3±n/a nM
Citation
 Naik, P; Murumkar, P; Giridhar, R; Yadav, MR Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorg Med Chem 18:8418-56 (2010) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50281848
Synonyms:
2-Ethyl-5,7-dimethyl-3-{4-[2-(2H-tetrazol-5-yl)-5H-1lambda*4*-thiophen-3-yl]-benzyl}-3H-imidazo[4,5-b]pyridine | 2-Ethyl-5,7-dimethyl-3-{4-[2-(2H-tetrazol-5-yl)-thiophen-3-yl]-benzyl}-3H-imidazo[4,5-b]pyridine | CHEMBL58156 | L-158827
Type:
Small organic molecule
Emp. Form.:
C22H21N7S
Mol. Mass.:
415.514
SMILES:
CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccsc1-c1nnn[nH]1
Structure:
Search PDB for entries with ligand similarity: