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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50336705
Substrate
n/a
Meas. Tech.
ChEMBL_723415 (CHEMBL1676314)
IC50
1060±n/a nM
Citation
 Chatzopoulou, M; Mamadou, E; Juskova, M; Koukoulitsa, C; Nicolaou, I; Stefek, M; Demopoulos, VJ Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity. Bioorg Med Chem 19:1426-33 (2011) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50336705
Synonyms:
(1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)(phenyl)methanone | CHEMBL1673030
Type:
Small organic molecule
Emp. Form.:
C17H11F2NO2
Mol. Mass.:
299.2715
SMILES:
Oc1c(F)cc(cc1F)-n1cccc1C(=O)c1ccccc1
Structure:
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