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Target
Signal transducer and activator of transcription 1
Ligand
BDBM50337198
Substrate
n/a
Meas. Tech.
ChEMBL_726325 (CHEMBL1687313)
Ki
16500±n/a nM
Citation
 Shahani, VM; Yue, P; Fletcher, S; Sharmeen, S; Sukhai, MA; Luu, DP; Zhang, X; Sun, H; Zhao, W; Schimmer, AD; Turkson, J; Gunning, PT Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein. Bioorg Med Chem 19:1823-38 (2011) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 1
Synonyms:
STAT1_MOUSE | Stat1
Type:
PROTEIN
Mol. Mass.:
87184.30
Organism:
Mus musculus
Description:
ChEMBL_863014
Residue:
749
Sequence:
MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEIKTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQTWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKSRLLVKLQESNLLTKVKCHFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAELRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKNDLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGPEFDSMMSTV
  
Inhibitor
Name:
BDBM50337198
Synonyms:
(S)-3-(((S)-1-((5-(Benzylcarbamoyl)-4'-carbamoyl-[1,1'-biphenyl]-3-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-(4-cyanobenzamido)-3-oxopropyl)phenyl dihydrogen phosphate | CHEMBL1681824
Type:
Small organic molecule
Emp. Form.:
C44H43N6O9P
Mol. Mass.:
830.8208
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1cc(cc(c1)-c1ccc(cc1)C(N)=O)C(=O)NCc1ccccc1 |r|
Structure:
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