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Target
Thymidylate synthase
Ligand
BDBM50340675
Substrate
n/a
Meas. Tech.
ChEMBL_740134 (CHEMBL1763194)
IC50
>10000±n/a nM
Citation
 Tzioumaki, N; Manta, S; Tsoukala, E; Vande Voorde, J; Liekens, S; Komiotis, D; Balzarini, J Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase. Eur J Med Chem 46:993-1005 (2011) [PubMed]  Article 
Target
Name:
Thymidylate synthase
Synonyms:
TS | TSase | TYSY_MOUSE | Tyms
Type:
PROTEIN
Mol. Mass.:
34957.15
Organism:
Mus musculus
Description:
ChEMBL_1340097
Residue:
307
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
  
Inhibitor
Name:
BDBM50340675
Synonyms:
(S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyran-2-yl)pyrimidin-2(1H)-one | CHEMBL1762220
Type:
Small organic molecule
Emp. Form.:
C9H7FN2O4
Mol. Mass.:
226.1613
SMILES:
Fc1cn([C@H]2OCC=CC2=O)c(=O)[nH]c1=O |r,c:7|
Structure:
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