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Target
Dual specificity protein phosphatase 3
Ligand
BDBM50308719
Substrate
n/a
Meas. Tech.
ChEMBL_787847 (CHEMBL1918613)
IC50
>100000±n/a nM
Citation
 Liu, D; Kong, G; Chen, QC; Wang, G; Li, J; Xu, Y; lin, T; Tian, Y; Zhang, X; Yao, X; Feng, G; Lu, Z; Chen, H Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. Bioorg Med Chem Lett 21:6833-7 (2011) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50308719
Synonyms:
(9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one) | CHEMBL453805 | Imperatorin
Type:
Small organic molecule
Emp. Form.:
C16H14O4
Mol. Mass.:
270.28
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-c1c2occc2cc2ccc(=O)oc12
Structure:
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