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Target
Matrilysin
Ligand
BDBM8465
Substrate
n/a
Meas. Tech.
ChEMBL_799078 (CHEMBL1942019)
IC50
380±n/a nM
Citation
 Marques, SM; Tuccinardi, T; Nuti, E; Santamaria, S; André, V; Rossello, A; Martinelli, A; Santos, MA Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases. J Med Chem 54:8289-98 (2011) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM8465
Synonyms:
(2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylmethyl)sulfonamido]-3-methylbutanamide | BMCL16311 Compound 1a | CGS 27023 | CGS 27023A | CHEMBL514138 | hydroxamate analogue 1
Type:
Small organic molecule
Emp. Form.:
C18H23N3O5S
Mol. Mass.:
393.457
SMILES:
COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO |r|
Structure:
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