Compile Data Set for Download or QSAR
maximum 50k data
Found 789 with Last Name = 'santamaria' and Initial = 's'
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50294132(CHEMBL561963 | N-hydroxy-2-(N-isopropoxy-4'-isopro...)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50294132(CHEMBL561963 | N-hydroxy-2-(N-isopropoxy-4'-isopro...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of MMP13-mediated collagen degradation by SDS-PAGEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50294122(CHEMBL560837 | N-Hydroxy-2-(N-isopropoxy-4'-methox...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50161331(2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydro...)
Affinity DataKi:  13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50294124(2-(4'-(4-Chlorobenzyloxy)-N-isopropoxybiphenyl-4-y...)
Affinity DataKi:  25nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50294131((R)-2-(4'-(4-Chlorobenzyloxy)-N-isopropoxybiphenyl...)
Affinity DataKi:  29nMAssay Description:Inhibition of MMP13-mediated collagen degradation by SDS-PAGEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50429815(CHEMBL2337698)
Affinity DataKi:  77nMAssay Description:Inhibition of human recombinant ADAMTS5 using bovine nasal cartilage aggrecan as substrate assessed as inhibition of 1772-AGEG neopeptide formation i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50104963((2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-(...)
Affinity DataKi:  321nMAssay Description:Inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataKi:  840nMAssay Description:Inhibition of human recombinant ADAMTS5 using bovine nasal cartilage aggrecan as substrate assessed as inhibition of 1772-AGEG neopeptide formation i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of ADAMTS-5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))TBA
LigandPNGBDBM50104963((2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-(...)
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))TBA
LigandPNGBDBM50031472(1,2,3-Trihydroxybenzene, XIV | CHEMBL307145 | Pyro...)
Affinity DataKi:  2.03E+3nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))TBA
LigandPNGBDBM50126057((2R,3S)-N*4*-Hydroxy-2-(3-hydroxy-benzyl)-N*1*-((1...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Affinity DataKi:  2.68E+3nMAssay Description:Inhibition of ADAMTS-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Aarhus University

Curated by ChEMBL
LigandPNGBDBM50398075(CHEMBL2182012)
Affinity DataKi:  3.50E+3nMAssay Description:Uncompetitive inhibition of human neutrophil elastase assessed as hydrolysis of N-succinyl-Ala-Ala-Pro-Val-p-nitroanilide incubated for 2 hrs measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50031472(1,2,3-Trihydroxybenzene, XIV | CHEMBL307145 | Pyro...)
Affinity DataKi:  3.63E+3nMAssay Description:Inhibition of ADAMTS-5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50104965((2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50031472(1,2,3-Trihydroxybenzene, XIV | CHEMBL307145 | Pyro...)
Affinity DataKi:  3.89E+3nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Aarhus University

Curated by ChEMBL
LigandPNGBDBM50398081(CHEMBL2182013)
Affinity DataKi:  4.00E+3nMAssay Description:Uncompetitive inhibition of human neutrophil elastase assessed as hydrolysis of N-succinyl-Ala-Ala-Pro-Val-p-nitroanilide incubated for 2 hrs measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))TBA
LigandPNGBDBM50104965((2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R...)
Affinity DataKi:  4.14E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50031472(1,2,3-Trihydroxybenzene, XIV | CHEMBL307145 | Pyro...)
Affinity DataKi:  4.43E+3nMAssay Description:Inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))TBA
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Affinity DataKi:  4.77E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104963((2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-(...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Aarhus University

Curated by ChEMBL
LigandPNGBDBM50398080(CHEMBL2182014)
Affinity DataKi:  5.00E+3nMAssay Description:Uncompetitive inhibition of human neutrophil elastase assessed as hydrolysis of N-succinyl-Ala-Ala-Pro-Val-p-nitroanilide incubated for 2 hrs measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))TBA
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Affinity DataKi:  5.57E+3nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50031472(1,2,3-Trihydroxybenzene, XIV | CHEMBL307145 | Pyro...)
Affinity DataKi:  6.34E+3nMAssay Description:Inhibition of ADAMTS-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))TBA
LigandPNGBDBM50031472(1,2,3-Trihydroxybenzene, XIV | CHEMBL307145 | Pyro...)
Affinity DataKi:  7.01E+3nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterstitial collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50104963((2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-(...)
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterstitial collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50104965((2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R...)
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50104965((2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R...)
Affinity DataKi: >8.10E+3nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Affinity DataKi:  8.71E+3nMAssay Description:Inhibition of MMP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Affinity DataKi:  1.04E+4nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Aarhus University

Curated by ChEMBL
LigandPNGBDBM50398079(CHEMBL2182018)
Affinity DataKi:  1.30E+4nMAssay Description:Noncompetitive inhibition of human neutrophil elastase assessed as hydrolysis of N-succinyl-Ala-Ala-Pro-Val-p-nitroanilide incubated for 2 hrs measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Aarhus University

Curated by ChEMBL
LigandPNGBDBM50398078(CHEMBL2182019)
Affinity DataKi:  1.80E+4nMAssay Description:Noncompetitive inhibition of human neutrophil elastase assessed as hydrolysis of N-succinyl-Ala-Ala-Pro-Val-p-nitroanilide incubated for 2 hrs measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50429818(CHEMBL2337691)
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition of human recombinant ADAMTS5 using bovine nasal cartilage aggrecan as substrate assessed as inhibition of 1772-AGEG neopeptide formation i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50175548(CHEMBL198778 | N-Hydroxy-2-(4-phenoxy-benzenesulfo...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant MMP13 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))TBA
LigandPNGBDBM50299051(CHEMBL573715 | N-Hydroxy-2-{2-[4-(4-methoxy-phenox...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))TBA
LigandPNGBDBM50161330((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50429816(CHEMBL2337697)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50429816(CHEMBL2337697)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of human recombinant MMP13 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50314223((R)-2-(4-(but-2-ynyloxy)phenylsulfonamido)-4-(1,3-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50161330((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP2 catalytic domain after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))TBA
LigandPNGBDBM50299051(CHEMBL573715 | N-Hydroxy-2-{2-[4-(4-methoxy-phenox...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP9 catalytic domain after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))TBA
LigandPNGBDBM50299051(CHEMBL573715 | N-Hydroxy-2-{2-[4-(4-methoxy-phenox...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 1 hr preincubation by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))TBA
LigandPNGBDBM50299051(CHEMBL573715 | N-Hydroxy-2-{2-[4-(4-methoxy-phenox...)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 30 mins preincubation by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50314221((R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoin...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))TBA
LigandPNGBDBM50314221((R)-2-(4-bromophenylsulfonamido)-4-(1,3-dioxoisoin...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346803(CHEMBL1795862)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 789 total ) | Next | Last >>
Jump to: