Reaction Details Report a problem with these data
Target
Inactive phospholipase C-like protein 1
Ligand
BDBM50075183
Substrate
n/a
Meas. Tech.
ChEMBL_90102 (CHEMBL699699)
IC50
40.0±n/a nM
Citation
 Riley, AM; Murphy, CT; Lindley, CJ; Westwick, J; Potter, BV 6-Deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate: A potent agonist at the inositol 1,4,5-trisphosphate receptor Bioorg Med Chem Lett 6:2197-2200 (1996)    Article 
Target
Name:
Inactive phospholipase C-like protein 1
Synonyms:
Inositol 1,4,5-trisphosphate binding protein | PLCL1_RAT | Plcl1
Type:
PROTEIN
Mol. Mass.:
122756.49
Organism:
Rattus norvegicus
Description:
ChEMBL_90102
Residue:
1096
Sequence:
MAEGAASREAPAPLDVAGGEDDPRAGADAASGDAAPEASGGRMRDRRSGVALPGNAGVPADSEAGLLEAARATPRRTSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEVEQGVTHVTEDMCLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQQRVMVQQMKKVFGNKLYTEAPLSSESYLPSPEKLKHMIIVKGKKLPSESDLLEGEVTDEDEEAEMSRRVSGDYNGEQKHIWLCRELSDLVSICKSVQYRDFELSMKTQNYWEICSFSETLASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKELCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGTIPDVQKRMLAAYDLMIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAWNITVLKGQGDLLKNAKNEAVENIKQIQLACLSCGLSKGPGSAAEAKGKRSLEAIEEKESSEENGKL
  
Inhibitor
Name:
BDBM50075183
Synonyms:
1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate | 1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) | 1D-myo-inositol 1,4,5-trisphosphate | 3,5,6-trioxyphosphate-1,2,4-cyclohexanetriol | CHEMBL279107 | D-myo-inositol 1,4,5-trisphosphate | IP3 | InsP3
Type:
Small organic molecule
Emp. Form.:
C6H15O15P3
Mol. Mass.:
420.0956
SMILES:
O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
Structure:
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