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Target
Interstitial collagenase
Ligand
BDBM50078567
Substrate
n/a
Meas. Tech.
ChEBML_101748
IC50
384±n/a nM
Citation
 Hanessian, S; Bouzbouz, S; Boudon, A; Tucker, GC; Peyroulan, D Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors. Bioorg Med Chem Lett 9:1691-6 (1999) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50078567
Synonyms:
(S)-N-Hydroxy-2-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-butyramide | CHEMBL45357
Type:
Small organic molecule
Emp. Form.:
C15H24N2O5S
Mol. Mass.:
344.426
SMILES:
CC[C@H](N(CC(C)C)S(=O)(=O)c1ccc(OC)cc1)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: