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Target
Plasminogen
Ligand
BDBM50074917
Substrate
n/a
Meas. Tech.
ChEBML_155604
Ki
560±n/a nM
Citation
 Garrett, GS; McPhail, SJ; Tornheim, K; Correa, PE; McIver, JM Synthesis of potent and selective inhibitors of human plasma kallikrein. Bioorg Med Chem Lett 9:301-6 (1999) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
PLMN_RAT | Plasmin | Plasminogen | Plg
Type:
Protein
Mol. Mass.:
90541.87
Organism:
Rattus norvegicus
Description:
Q01177
Residue:
812
Sequence:
MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAGSIADCLAKCEGETDFICRSFQYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGKGYRGTMSKTKTGVTCQKWSDTSPHVPKYSPSTHPSEGLEENYCRNPDNDEQGPWCYTTDPDQRYEYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQSWDSQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEYCDIPRCTTPPPPPGPTYQCLKGRGENYRGTVSVTASGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIPSCGSSVSPDQSDSSVLPEQTPVVQECYQGNGKSYRGTSSTTNTGKKCQSWVSMTPHSHSKTPANFPDAGLEMNYCRNPDNDQRGPWCFTTDPSVRWEYCNLKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYRGKTAVTAAGTPCQEWAAQEPHSHRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLCASLSSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAHCLEKSSRPEFYKVILGAHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDNVIPACLPSPNYVVADRTLCYITGWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRYVNWIEREMRND
  
Inhibitor
Name:
BDBM50074917
Synonyms:
Morpholine-4-carboxylic acid ((R)-2,2-dimethyl-1-{(S)-2-phenyl-1-[3,3,3-trifluoro-1-(4-guanidino-benzyl)-2-oxo-propylcarbamoyl]-ethylcarbamoyl}-propyl)-amide
Type:
Small organic molecule
Emp. Form.:
C31H41F3N7O5
Mol. Mass.:
648.6958
SMILES:
CC(C)(C)[C@@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NC(Cc1ccc(NC(N)=[NH2+])cc1)C(=O)C(F)(F)F
Structure:
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