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Found 311 with Last Name = 'mcphail' and Initial = 'sj'
TargetPlasma kallikrein(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074918(((R)-2,2-Dimethyl-1-{(S)-2-phenyl-1-[3,3,3-trifluo...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity of compound against human plasma Kallikrein (PK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074920(((R)-3-Phenyl-1-{(S)-2-phenyl-1-[3,3,3-trifluoro-1...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity of compound against human plasma Kallikrein (PK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074915(((R)-2-Methyl-1-{(S)-2-phenyl-1-[3,3,3-trifluoro-1...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity of compound against human plasma Kallikrein (PK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  8nMAssay Description:Inhibition of truncated gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  8nMAssay Description:Inhibition of human matrix metalloprotease 9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  20nMAssay Description:Inhibition of human matrix metalloprotease 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074917(Morpholine-4-carboxylic acid ((R)-2,2-dimethyl-1-{...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity of compound against human plasma Kallikrein (PK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  33nMAssay Description:Inhibition of truncated collagenase-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  33nMAssay Description:Inhibition of human matrix metalloprotease 1More data for this Ligand-Target Pair
TargetPlasminogen(Rattus norvegicus)
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074920(((R)-3-Phenyl-1-{(S)-2-phenyl-1-[3,3,3-trifluoro-1...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity of compound against Plasmin (HP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  43nMAssay Description:Inhibition of truncated stromelysin (Matrix metalloprotease-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  43nMAssay Description:Inhibition of human matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074921([(R)-1-({(S)-Naphthalen-2-yl-[3,3,3-trifluoro-1-(4...)
Affinity DataKi:  60nMAssay Description:Inhibitory activity of compound against Plasmin (HP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074915(((R)-2-Methyl-1-{(S)-2-phenyl-1-[3,3,3-trifluoro-1...)
Affinity DataKi:  80nMAssay Description:Inhibitory activity of compound against Plasmin (HP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074921([(R)-1-({(S)-Naphthalen-2-yl-[3,3,3-trifluoro-1-(4...)
Affinity DataKi:  89nMAssay Description:Inhibitory activity of compound against human plasma Kallikrein (PK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074918(((R)-2,2-Dimethyl-1-{(S)-2-phenyl-1-[3,3,3-trifluo...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity of compound against Plasmin (HP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074916([(R)-2,2-Dimethyl-1-({(S)-naphthalen-2-yl-[3,3,3-t...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity of compound against Plasmin (HP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074916([(R)-2,2-Dimethyl-1-({(S)-naphthalen-2-yl-[3,3,3-t...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity of compound against human plasma Kallikrein (PK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074917(Morpholine-4-carboxylic acid ((R)-2,2-dimethyl-1-{...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity of compound against Plasmin (HP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074920(((R)-3-Phenyl-1-{(S)-2-phenyl-1-[3,3,3-trifluoro-1...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibitory activity of compound against Tissue Kallikrein (TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074919(Morpholine-4-carboxylic acid [(R)-2,2-dimethyl-1-(...)
Affinity DataKi:  1.55E+4nMAssay Description:Inhibitory activity of compound against human plasma Kallikrein (PK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074918(((R)-2,2-Dimethyl-1-{(S)-2-phenyl-1-[3,3,3-trifluo...)
Affinity DataKi:  4.73E+4nMAssay Description:Inhibitory activity of compound against Tissue Kallikrein (TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074916([(R)-2,2-Dimethyl-1-({(S)-naphthalen-2-yl-[3,3,3-t...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity of compound against Tissue Kallikrein (TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074919(Morpholine-4-carboxylic acid [(R)-2,2-dimethyl-1-(...)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibitory activity of compound against Plasmin (HP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074919(Morpholine-4-carboxylic acid [(R)-2,2-dimethyl-1-(...)
Affinity DataKi: >1.50E+5nMAssay Description:Inhibitory activity of compound against Tissue Kallikrein (TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074915(((R)-2-Methyl-1-{(S)-2-phenyl-1-[3,3,3-trifluoro-1...)
Affinity DataKi:  1.91E+5nMAssay Description:Inhibitory activity of compound against Tissue Kallikrein (TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074921([(R)-1-({(S)-Naphthalen-2-yl-[3,3,3-trifluoro-1-(4...)
Affinity DataKi:  2.23E+5nMAssay Description:Inhibitory activity of compound against Tissue Kallikrein (TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
The Procter & Gamble

Curated by ChEMBL
LigandPNGBDBM50074917(Morpholine-4-carboxylic acid ((R)-2,2-dimethyl-1-{...)
Affinity DataKi: >2.50E+6nMAssay Description:Inhibitory activity of compound against Tissue Kallikrein (TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084743(4-Methanesulfonyl-1-(4-methoxy-benzenesulfonyl)-pi...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084726(4-(Biphenyl-4-carbonyl)-1-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084759(4-(2-Hydroxy-3-methyl-butyryl)-1-(4-methoxy-benzen...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084729(4-Acetyl-1-(4-methoxy-benzenesulfonyl)-piperazine-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084734(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084743(4-Methanesulfonyl-1-(4-methoxy-benzenesulfonyl)-pi...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084731(4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicar...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084741(1,4-Bis-(4-methoxy-benzenesulfonyl)-piperazine-2-c...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084744(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084754(1-(4-Methoxy-benzenesulfonyl)-4-(thiophene-2-carbo...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084741(1,4-Bis-(4-methoxy-benzenesulfonyl)-piperazine-2-c...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084761(4-(3,5-Dimethyl-isoxazole-4-sulfonyl)-1-(4-methoxy...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084730(4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicar...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084747(4-(cyclohexanecarbonyl)-N-hydroxy-1-(4-methoxyphen...)
Affinity DataIC50:  1.5nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084746(4-(Furan-2-carbonyl)-1-(4-methoxy-benzenesulfonyl)...)
Affinity DataIC50:  1.60nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082536(1-(4-Methoxy-benzenesulfonyl)-piperazine-2-carboxy...)
Affinity DataIC50:  1.70nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084745(4-Hexanoyl-1-(4-methoxy-benzenesulfonyl)-piperazin...)
Affinity DataIC50:  1.70nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084745(4-Hexanoyl-1-(4-methoxy-benzenesulfonyl)-piperazin...)
Affinity DataIC50:  1.70nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084747(4-(cyclohexanecarbonyl)-N-hydroxy-1-(4-methoxyphen...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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