Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM50147223
Substrate
n/a
Meas. Tech.
ChEMBL_214396 (CHEMBL819417)
IC50
4±n/a nM
Citation
Xiang, MA; Chen, RH; Demarest, KT; Gunnet, J; Look, R; Hageman, W; Murray, WV; Combs, DW; Rybczynski, PJ; Patel, M Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists. Bioorg Med Chem Lett 14:3143-6 (2004) [PubMed] Article
More Info.:
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
Inhibitor
Name:
BDBM50147223
Synonyms:
3'N-(2-hydroxyethyl)-1-[4-(2-fluorophenylcarboxamido)benzoyl]spiro[2,3,4,5-tetrahydro-1H-benzo[b]azepine-4,1'-(2'-cyclopentene)]-3'-carboxamide | CHEMBL109166
Type:
Small organic molecule
Emp. Form.:
C31H30FN3O4
Mol. Mass.:
527.586
SMILES:
OCCNC(=O)C1=CC2(CC1)CCN(C(=O)c1ccc(NC(=O)c3ccccc3F)cc1)c1ccccc1C2 |t:6|