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Target
Tyrosine-protein kinase transforming protein Abl
Ligand
BDBM50292487
Substrate
n/a
Meas. Tech.
ChEBML_221791
IC50
50000±n/a nM
Citation
 Kruse, CH; Holden, KG; Pritchard, ML; Feild, JA; Rieman, DJ; Greig, RG; Poste, G Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 1. J Med Chem 31:1762-7 (1988) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase transforming protein Abl
Synonyms:
ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL
Type:
Enzyme
Mol. Mass.:
81895.89
Organism:
Abelson murine leukemia virus
Description:
P00521
Residue:
746
Sequence:
YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRTCRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKVGLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEAGGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPSTAPAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGPAATQDFSKLLSSVKEISDIVRR
  
Inhibitor
Name:
BDBM50292487
Synonyms:
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 4-(N-phenethylsulfamoyl)benzoate | CHEMBL521515
Type:
Small organic molecule
Emp. Form.:
C25H26N6O7S
Mol. Mass.:
554.575
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COC(=O)c2ccc(cc2)S(=O)(=O)NCCc2ccccc2)[C@@H](O)[C@H]1O |r|
Structure:
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