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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50038212
Substrate
n/a
Meas. Tech.
ChEBML_139962
Ki
460±n/a nM
Citation
 Tsukamoto, S; Ichihara, M; Wanibuchi, F; Usuda, S; Hidaka, K; Harada, M; Tamura, T Synthesis and structure-activity studies of a series of spirooxazolidine-2,4-diones: 4-oxa analogues of the muscarinic agonist 2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione. J Med Chem 36:2292-9 (1993) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50038212
Synonyms:
2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-dione | 2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-dione (RS-86) | 2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-dione(RS-86) | CHEMBL273308 | CHEMBL542883
Type:
Small organic molecule
Emp. Form.:
C11H18N2O2
Mol. Mass.:
210.2728
SMILES:
CCN1C(=O)CC2(CCN(C)CC2)C1=O
Structure:
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