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Found 644 with Last Name = 'tamura' and Initial = 't'
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  25nMAssay Description:Inhibition of carbonic anhydrase 1 in human RBC cells by SDS-PAGE/fluorescence gel imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044692(3-tert-Butyl-8-methyl-2-thioxo-1-oxa-3,8-diaza-spi...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50038212(2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-di...)
Affinity DataKi:  460nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044702(3-Ethyl-8-methyl-2-thioxo-1-oxa-3,8-diaza-spiro[4....)
Affinity DataKi:  890nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50038212(2-Ethyl-8-methyl-2,8-diaza-spiro[4.5]decane-1,3-di...)
Affinity DataKi:  970nMAssay Description:Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044704(3-tert-Butyl-8-methyl-1-oxa-3,8-diaza-spiro[4.5]de...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044692(3-tert-Butyl-8-methyl-2-thioxo-1-oxa-3,8-diaza-spi...)
Affinity DataKi:  2.10E+3nMAssay Description:Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Keio University

Curated by ChEMBL
LigandPNGBDBM50590308(CHEMBL5201689)
Affinity DataKi:  3.02E+3nMAssay Description:Competitive inhibition of biotinylated heparin binding to His-tagged wild type SARS-COV-2 spike protein assessed inhibition constant incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM12414(CHEMBL27601 | benzenesulfonamide | hCA inhibitor, ...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of carbonic anhydrase 1 in human RBC cells by SDS-PAGE/fluorescence gel imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM4703(4-carboxybenzenesulfonamide 1 | 4-sulfamoylbenzoic...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of carbonic anhydrase 1 in human RBC cells by SDS-PAGE/fluorescence gel imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044701(8-Methyl-3-phenyl-2-thioxo-1-oxa-3,8-diaza-spiro[4...)
Affinity DataKi:  4.00E+3nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044702(3-Ethyl-8-methyl-2-thioxo-1-oxa-3,8-diaza-spiro[4....)
Affinity DataKi:  4.30E+3nMAssay Description:Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044696(3-Ethyl-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decane-...)
Affinity DataKi:  5.00E+3nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044695(3-Allyl-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decane-...)
Affinity DataKi:  5.10E+3nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044688(4-(8-Methyl-2,4-dioxo-1-oxa-3,8-diaza-spiro[4.5]de...)
Affinity DataKi:  6.40E+3nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044696(3-Ethyl-8-methyl-1-oxa-3,8-diaza-spiro[4.5]decane-...)
Affinity DataKi:  7.80E+3nMAssay Description:Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044708(3-Ethyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dione...)
Affinity DataKi:  7.80E+3nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044700((8-Methyl-2,4-dioxo-1-oxa-3,8-diaza-spiro[4.5]dec-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044703(8-Methyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-dion...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044698(4-(3-Ethyl-2,4-dioxo-1-oxa-3,8-diaza-spiro[4.5]dec...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044697((3-Chloro-phenyl)-carbamic acid 4-(3-ethyl-2,4-dio...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044689(2-(8-Methyl-2,4-dioxo-1-oxa-3,8-diaza-spiro[4.5]de...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044699(8-Benzyl-3-ethyl-1-oxa-3,8-diaza-spiro[4.5]decane-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044693(3-Ethyl-7-methyl-1-oxa-3,7-diaza-spiro[4.4]nonane-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044691(8-Methyl-3-(2-morpholin-4-yl-ethyl)-1-oxa-3,8-diaz...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044690(8-Methyl-2-thioxo-1-oxa-3,8-diaza-spiro[4.5]decan-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044706(3-Ethyl-7-methyl-1-oxa-3,7-diaza-spiro[4.5]decane-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044694(3-(3-Chloro-phenyl)-8-methyl-1-oxa-3,8-diaza-spiro...)
Affinity DataKi:  1.20E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Institute For Drug Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044707(3,8-Dimethyl-1-oxa-3,8-diaza-spiro[4.5]decane-2,4-...)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [3H]pirenzepine from rat cortex membrane expressing muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50318885(CHEMBL525610 | teriparatide)
Affinity DataIC50:  0.0800nMAssay Description:Displacement of 125I-PTH (1 to 15 residues) from human PTHR1 expressed in African green monkey COS7 cell membranes at 300 uM after 90 mins by gamma c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386696(CHEMBL2048911)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of N-terminus peptide-tagged human recombinant HER2 expressed using baculovirus infection system using [gamma-33P]-ATP preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386693(CHEMBL2048912)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of N-terminus peptide-tagged human recombinant HER2 expressed using baculovirus infection system using [gamma-33P]-ATP preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386694(CHEMBL2048789)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of N-terminus peptide-tagged human recombinant HER2 expressed using baculovirus infection system using [gamma-33P]-ATP preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108434(US8609688, 12)
Affinity DataIC50:  1.44nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108434(US8609688, 12)
Affinity DataIC50:  1.44nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108430(US8609688, 8)
Affinity DataIC50:  1.5nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108430(US8609688, 8)
Affinity DataIC50:  1.5nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386708(CHEMBL2048795)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of N-terminus peptide-tagged human recombinant HER2 expressed using baculovirus infection system using [gamma-33P]-ATP preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386707(CHEMBL2048796)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of N-terminus peptide-tagged human recombinant HER2 expressed using baculovirus infection system using [gamma-33P]-ATP preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386701(CHEMBL2048906)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of N-terminus peptide-tagged human recombinant HER2 expressed using baculovirus infection system using [gamma-33P]-ATP preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108428(US8609688, 6)
Affinity DataIC50:  1.63nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108428(US8609688, 6)
Affinity DataIC50:  1.63nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108426(US8609688, 4)
Affinity DataIC50:  1.70nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386704(CHEMBL2048903)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of N-terminus peptide-tagged human recombinant HER2 expressed using baculovirus infection system using [gamma-33P]-ATP preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108426(US8609688, 4)
Affinity DataIC50:  1.70nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108440(US8609688, 18)
Affinity DataIC50:  1.79nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108440(US8609688, 18)
Affinity DataIC50:  1.79nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108436(US8609688, 14)
Affinity DataIC50:  1.84nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108436(US8609688, 14)
Affinity DataIC50:  1.84nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386704(CHEMBL2048903)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of N-terminus peptide-tagged human recombinant EGFR expressed using baculovirus infection system using [gamma-33P]-ATP preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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