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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50044692
Substrate
n/a
Meas. Tech.
ChEBML_140113
Ki
2100±n/a nM
Citation
 Tsukamoto, S; Ichihara, M; Wanibuchi, F; Usuda, S; Hidaka, K; Harada, M; Tamura, T Synthesis and structure-activity studies of a series of spirooxazolidine-2,4-diones: 4-oxa analogues of the muscarinic agonist 2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione. J Med Chem 36:2292-9 (1993) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50044692
Synonyms:
3-tert-Butyl-8-methyl-2-thioxo-1-oxa-3,8-diaza-spiro[4.5]decan-4-one; hydrochloride | CHEMBL553865
Type:
Small organic molecule
Emp. Form.:
C12H20N2O2S
Mol. Mass.:
256.364
SMILES:
CN1CCC2(CC1)OC(=S)N(C2=O)C(C)(C)C
Structure:
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