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Target
Purine nucleoside phosphorylase
Ligand
BDBM50207401
Substrate
n/a
Meas. Tech.
ChEMBL_153329 (CHEMBL760481)
Ki
18700±n/a nM
Citation
 Chern, JW; Lee, HY; Chen, CS; Shewach, DS; Daddona, PE; Townsend, LB Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase. J Med Chem 36:1024-31 (1993) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50207401
Synonyms:
2-Amino-8-bromo-9-(2-hydroxy-ethoxymethyl)-1,9-dihydro-purin-6-one | 2-Amino-8-bromo-9-(2-hydroxy-ethoxymethyl)-9H-purin-6-ol | 2-amino-8-bromo-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one | CHEMBL223508
Type:
Small organic molecule
Emp. Form.:
C8H10BrN5O3
Mol. Mass.:
304.101
SMILES:
Nc1nc2n(COCCO)c(Br)nc2c(=O)[nH]1
Structure:
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