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Target
Neutrophil elastase
Ligand
BDBM50035493
Substrate
n/a
Meas. Tech.
ChEMBL_63992 (CHEMBL673102)
Ki
70±n/a nM
Citation
 Angelastro, MR; Baugh, LE; Bey, P; Burkhart, JP; Chen, TM; Durham, SL; Hare, CM; Huber, EW; Janusz, MJ; Koehl, JR Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones. J Med Chem 37:4538-53 (1995) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50035493
Synonyms:
(S)-1-[(S)-3-Methyl-2-(3-morpholin-4-yl-3-oxo-propionylamino)-butyryl]-pyrrolidine-2-carboxylic acid (3,3,4,4,4-pentafluoro-1-isopropyl-2-oxo-butyl)-amide | CHEMBL342660
Type:
Small organic molecule
Emp. Form.:
C24H35F5N4O6
Mol. Mass.:
570.5499
SMILES:
CC(C)[C@H](NC(=O)CC(=O)N1CCOCC1)C(=O)N1CCC[C@H]1C(=O)NC(C(C)C)C(=O)C(F)(F)C(F)(F)F
Structure:
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