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Target
Serine protease 1
Ligand
BDBM50052427
Substrate
n/a
Meas. Tech.
ChEMBL_212531 (CHEMBL815751)
Ki
>150000±n/a nM
Citation
 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. J Med Chem 39:3039-43 (1996) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM50052427
Synonyms:
2-{1-hydroxy-5-imino(4-methylphenylsulfonamido)methylamino-2-[1-(N-methylbenzyloxycarbonyl amino-3-phenylpropanoyl)tetrahydro-1H-2-pyrrolylcarboxamido]pentyl}benzo[d][1,3]thiazole | CHEMBL319615
Type:
Small organic molecule
Emp. Form.:
C43H49N7O7S2
Mol. Mass.:
840.022
SMILES:
CN([C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)C(O)c1nc2ccccc2s1)C(=O)OCc1ccccc1
Structure:
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