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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50077198
Substrate
n/a
Meas. Tech.
ChEMBL_221635 (CHEMBL823025)
Kd
3000±n/a nM
Citation
 Beaulieu, PL; Cameron, DR; Ferland, JM; Gauthier, J; Ghiro, E; Gillard, J; Gorys, V; Poirier, M; Rancourt, J; Wernic, D; Llinas-Brunet, M; Betageri, R; Cardozo, M; Hickey, ER; Ingraham, R; Jakes, S; Kabcenell, A; Kirrane, T; Lukas, S; Patel, U; Proudfoot, J; Sharma, R; Tong, L; Moss, N Ligands for the tyrosine kinase p56lck SH2 domain: discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements. J Med Chem 42:1757-66 (1999) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50077198
Synonyms:
(S)-4-(4-Methoxy-benzylcarbamoyl)-4-{(S)-2-(2-naphthalen-1-yl-acetylamino)-3-[4-(oxalyl-amino)-phenyl]-propionylamino}-butyric acid | CHEMBL297936
Type:
Small organic molecule
Emp. Form.:
C36H36N4O9
Mol. Mass.:
668.6924
SMILES:
COc1ccc(CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccc(NC(=O)C(O)=O)cc2)NC(=O)Cc2cccc3ccccc23)cc1
Structure:
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