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Target
Gag-Pol polyprotein
Ligand
BDBM50065788
Substrate
n/a
Meas. Tech.
ChEMBL_88784 (CHEMBL699442)
IC50
7400±n/a nM
Citation
 Ouali, M; Laboulais, C; Leh, H; Gill, D; Desmaële, D; Mekouar, K; Zouhiri, F; d'Angelo, J; Auclair, C; Mouscadet, JF; Le Bret, M Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives. J Med Chem 43:1949-57 (2000) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein
Synonyms:
POL_RSVP | Rous sarcoma virus integrase | gag-pol
Type:
PROTEIN
Mol. Mass.:
173907.80
Organism:
Rous sarcoma virus (strain Prague C) (RSV-PrC)
Description:
ChEMBL_88784
Residue:
1603
Sequence:
MEAVIKVISSACKTYCGKTSPSKKEIGAMLSLLQKEGLLMSPSDLYSPGSWDPITAALSQRAMILGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATERRIDKGEEVGETTVQRDAKMAPEETATPKTVGTSCYHCGTAIGCNCATASAPPPPYVGSGLYPSLAGVGEQQGQGGDTPPGAEQSRAEPGHAGQAPGPALTDWARVREELASTGPPVVAMPVVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITMAEVEALMSSPLLPHDVTNLMRVILGPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQGRGERTNLNRLKGLADGMVGNPQGQAALLRPGELVAITASALQAFREVARLAEPAGPWADIMQGPSESFVDFANRLIKAVEGSDLPPSARAPVIIDCFRQKSQPDIQQLIRTAPSTLTTPGEIIKYVLDRQKTAPLTDQGIAAAMSSAIQPLIMAVVNRERDGQTGSGGRARGLCYTCGSPGHYQAQCPKKRKSGNSRERCQLCNGMGHNAKQCRKRDGNQGQRPGKGLSSGPWPGPEPPAVSLAMTMEHKDRPLVRVILTNTGSHPVKQRSVYITALLDSGADITIISEEDWPTDWPVMEAANPQIHGIGGGIPMRKSRDMIELGVINRDGSLERPLLLFPAVAMVRGSILGRDCLQGLGLRLTNLIGRATVLTVALHLAIPLKWKPDHTPVWIDQWPLPEGKLVALTQLVEKELQLGHIEPSLSCWNTPVFVIRKASGSYRLLHDLRAVNAKLVPFGAVQQGAPVLSALPRGWPLMVLDLKDCFFSIPLAEQDREAFAFTLPSVNNQAPARRFQWKVLPQGMTCSPTICQLVVGQVLEPLRLKHPSLCMLHYMDDLLLAASSHDGLEAAGEEVISTLERAGFTISPDKVQREPGVQYLGYKLGSTYVAPVGLVAEPRIATLWDVQKLVGSLQWLRPALGIPPRLMGPFYEQLRGSDPNEAREWNLDMKMAWREIVRLSTTAALERWDPALPLEGAVARCEQGAIGVLGQGLSTHPRPCLWLFSTQPTKAFTAWLEVLTLLITKLRASAVRTFGKEVDILLLPACFREDLPLPEGILLALKGFAGKIRSSDTPSIFDIARPLHVSLKVRVTDHPVPGPTVFTDASSSTHKGVVVWREGPRWEIKEIADLGASVQQLEARAVAMALLLWPTTPTNVVTDSAFVAKMLLKMGQEGVPSTAAAFILEDALSQRSAMAAVLHVRSHSEVPGFFTEGNDVADSQATFQAYPLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGVNPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVAVQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQAMVERANRLLKDRIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFERGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVKNRDTDKVIWVPSRKVKPDITQKDEVTKKDEASPLFAGISDWIPWEDEQEGLQGETASNKQERPGEDTLAANES
  
Inhibitor
Name:
BDBM50065788
Synonyms:
(E)-2-(3-carboxy-4-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-(3-carboxy-4-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-[(E)-2-(3-Carboxy-4-hydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | 2-[2-(3-Carboxy-4-hydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | CHEMBL59548
Type:
Small organic molecule
Emp. Form.:
C19H13NO6
Mol. Mass.:
351.3096
SMILES:
OC(=O)c1ccc2ccc(\C=C\c3ccc(O)c(c3)C(O)=O)nc2c1O
Structure:
Search PDB for entries with ligand similarity: