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Target
Mu-type opioid receptor
Ligand
BDBM50154305
Substrate
n/a
Meas. Tech.
ChEMBL_303268 (CHEMBL828262)
Ki
23000±n/a nM
Citation
 Cardillo, G; Gentilucci, L; Tolomelli, A; Spinosa, R; Calienni, M; Qasem, AR; Spampinato, S Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-]. J Med Chem 47:5198-203 (2004) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50154305
Synonyms:
CHEMBL365889 | [(5R,9S,12R,14aR)-9-Benzyl-5-(4-hydroxy-benzyl)-12-(1H-indol-3-ylmethyl)-4,8,11,14-tetraoxo-dodecahydro-3a,6,7,10,13-pentaaza-cyclopentacyclotridecen-7-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C36H38N6O7
Mol. Mass.:
666.7229
SMILES:
OC(=O)CN1N[C@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C1=O
Structure:
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