Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50196683
Substrate
n/a
Meas. Tech.
ChEMBL_432048 (CHEMBL918245)
IC50
20000±n/a nM
Citation
 Iwakubo, M; Takami, A; Okada, Y; Kawata, T; Tagami, Y; Ohashi, H; Sato, M; Sugiyama, T; Fukushima, K; Iijima, H Design and synthesis of Rho kinase inhibitors (II). Bioorg Med Chem 15:350-64 (2006) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50196683
Synonyms:
CHEMBL224746 | N-(1-(pyridin-3-ylmethyl)piperidin-3-yl)-1H-indazol-5-amine | N-[1-(3-pyridylmethyl)-3-piperidyl]-N-(1H-5-indazolyl)amine
Type:
Small organic molecule
Emp. Form.:
C18H21N5
Mol. Mass.:
307.3928
SMILES:
C(N1CCCC(C1)Nc1ccc2[nH]ncc2c1)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: