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Target
Interstitial collagenase
Ligand
BDBM50227600
Substrate
n/a
Meas. Tech.
ChEMBL_459968 (CHEMBL943096)
IC50
50000±n/a nM
Citation
 Hayashi, R; Jin, X; Cook, GR Synthesis and evaluation of novel heterocyclic MMP inhibitors. Bioorg Med Chem Lett 17:6864-70 (2008) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50227600
Synonyms:
CHEMBL254837 | but-2-ynyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C10H9NO3
Mol. Mass.:
191.1834
SMILES:
CC#CCOC(=O)c1cccc(=O)[nH]1
Structure:
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