Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50375040
Substrate
n/a
Meas. Tech.
ChEMBL_470222 (CHEMBL923682)
IC50
21±n/a nM
Citation
 Imaeda, Y; Kawamoto, T; Tobisu, M; Konishi, N; Hiroe, K; Kawamura, M; Tanaka, T; Kubo, K Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active factor Xa inhibitors. Bioorg Med Chem 16:3125-40 (2008) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50375040
Synonyms:
CHEMBL409851
Type:
Small organic molecule
Emp. Form.:
C24H23ClN4O3S
Mol. Mass.:
482.982
SMILES:
Clc1ccc2cc(ccc2c1)S(=O)(=O)CCC(=O)N1CCN(CC1)c1cccc2nccn12
Structure:
Search PDB for entries with ligand similarity: