Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50260803
Substrate
n/a
Meas. Tech.
ChEMBL_556337 (CHEMBL954070)
Ki
1.2±n/a nM
Citation
 Wustrow, DJ; Maynard, GD; Yuan, J; Zhao, H; Mao, J; Guo, Q; Kershaw, M; Hammer, J; Brodbeck, RM; Near, KE; Zhou, D; Beers, DS; Chenard, BL; Krause, JE; Hutchison, AJ Aminopyrazine CB1 receptor inverse agonists. Bioorg Med Chem Lett 18:3376-81 (2008) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50260803
Synonyms:
1-(6-(2-chloropyridin-4-yl)-5-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-3-(ethylamino)azetidine-3-carboxamide | CHEMBL498783
Type:
Small organic molecule
Emp. Form.:
C22H20ClF3N6O
Mol. Mass.:
476.882
SMILES:
CCNC1(CN(C1)c1cnc(-c2ccc(cc2)C(F)(F)F)c(n1)-c1ccnc(Cl)c1)C(N)=O
Structure:
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