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Target
Asparagine synthetase [glutamine-hydrolyzing]
Ligand
BDBM50378579
Substrate
n/a
Meas. Tech.
ChEMBL_601140 (CHEMBL1074555)
Ki
20000±n/a nM
Citation
 Ikeuchi, H; Meyer, ME; Ding, Y; Hiratake, J; Richards, NG A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase. Bioorg Med Chem 17:6641-50 (2009) [PubMed]  Article 
Target
Name:
Asparagine synthetase [glutamine-hydrolyzing]
Synonyms:
ASNS | ASNS_HUMAN | Asparagine synthetase | TS11
Type:
PROTEIN
Mol. Mass.:
64373.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_851327
Residue:
561
Sequence:
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQPIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGVFAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFNNAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAARKVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNSWFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPKWINATDPSARTLTHYKSAVKA
  
Inhibitor
Name:
BDBM50378579
Synonyms:
CHEMBL1627258
Type:
Small organic molecule
Emp. Form.:
C14H22N7O9PS
Mol. Mass.:
495.405
SMILES:
CS(=O)(CC(=N)C(O)=O)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
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