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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50379290
Substrate
n/a
Meas. Tech.
ChEMBL_811405 (CHEMBL2013617)
IC50
>30000±n/a nM
Citation
 Lee, J; Lee, YM; Lee, BW; Kim, JH; Kim, JS Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities. J Nat Prod 75:267-70 (2012) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50379290
Synonyms:
CHEMBL2011644
Type:
Small organic molecule
Emp. Form.:
C31H44O10
Mol. Mass.:
576.6751
SMILES:
CC1=CC[C@H](O)[C@@]2(C)[C@H](CC(=O)C=Cc3ccc(O)cc3)C[C@H]([C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]12)C(C)(C)O |r,w:12.11,t:1|
Structure:
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