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Target
Solute carrier family 2, facilitated glucose transporter member 1
Ligand
BDBM50388391
Substrate
n/a
Meas. Tech.
ChEMBL_829819 (CHEMBL2061377)
IC50
5000±n/a nM
Citation
 Wang, D; Chu, PC; Yang, CN; Yan, R; Chuang, YC; Kulp, SK; Chen, CS Development of a novel class of glucose transporter inhibitors. J Med Chem 55:3827-36 (2012) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 1
Synonyms:
GLUT-1 | GLUT1 | GTR1_HUMAN | Glucose Transporter 1 (hGLUT1) | Glucose transporter | Glucose transporter type 1, erythrocyte/brain | HepG2 glucose transporter | SLC2A1
Type:
Protein
Mol. Mass.:
54091.71
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
492
Sequence:
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
  
Inhibitor
Name:
BDBM50388391
Synonyms:
CHEMBL2057965
Type:
Small organic molecule
Emp. Form.:
C17H18F3NO3S
Mol. Mass.:
373.39
SMILES:
CCC(CC)CN1C(=O)S\C(=C/c2ccc(O)c(c2)C(F)(F)F)C1=O
Structure:
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