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Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM50398366
Substrate
n/a
Meas. Tech.
ChEMBL_875897 (CHEMBL2187635)
IC50
132±n/a nM
Citation
 Blake, JF; Xu, R; Bencsik, JR; Xiao, D; Kallan, NC; Schlachter, S; Mitchell, IS; Spencer, KL; Banka, AL; Wallace, EM; Gloor, SL; Martinson, M; Woessner, RD; Vigers, GP; Brandhuber, BJ; Liang, J; Safina, BS; Li, J; Zhang, B; Chabot, C; Do, S; Lee, L; Oeh, J; Sampath, D; Lee, BB; Lin, K; Liederer, BM; Skelton, NJ Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. J Med Chem 55:8110-27 (2012) [PubMed]  Article 
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:
Enzyme
Mol. Mass.:
55681.25
Organism:
Homo sapiens (Human)
Description:
P31749
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM50398366
Synonyms:
CHEMBL2177367
Type:
Small organic molecule
Emp. Form.:
C28H38ClN5O3
Mol. Mass.:
528.086
SMILES:
CO[C@H]1CC[C@@H](CC1)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1 |r,wU:27.29,10.10,5.8,wD:24.26,2.1,(22.8,-34.77,;21.46,-35.53,;21.46,-37.07,;20.12,-37.83,;20.11,-39.37,;21.44,-40.13,;22.77,-39.38,;22.78,-37.85,;21.44,-41.67,;20.11,-42.44,;20.11,-43.98,;21.44,-44.75,;22.78,-43.98,;21.44,-46.3,;20.11,-47.07,;20.11,-48.61,;21.44,-49.38,;22.78,-48.61,;22.78,-47.07,;21.44,-50.92,;22.78,-51.68,;22.77,-53.23,;21.43,-54,;20.09,-53.22,;18.64,-53.7,;18.17,-55.16,;17.74,-52.46,;18.63,-51.21,;18.15,-49.75,;20.09,-51.69,;18.77,-44.75,;18.77,-46.29,;17.45,-47.06,;16.1,-46.29,;14.77,-47.06,;16.1,-44.75,;17.44,-43.97,)|
Structure:
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