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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50413414
Substrate
n/a
Meas. Tech.
ChEMBL_562387 (CHEMBL1018820)
IC50
79.43±n/a nM
Citation
 Budzik, B; Wang, Y; Shi, D; Wang, F; Xie, H; Wan, Z; Zhu, C; Foley, JJ; Nuthulaganti, P; Kallal, LA; Sarau, HM; Morrow, DM; Moore, ML; Rivero, RA; Palovich, M; Salmon, M; Belmonte, KE; Laine, DI; Jin, J M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines. Bioorg Med Chem Lett 19:1686-90 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50413414
Synonyms:
CHEMBL492988
Type:
Small organic molecule
Emp. Form.:
C27H27N3O3
Mol. Mass.:
441.5216
SMILES:
O=C(NCc1cccc(c1)-c1cccc(CN2C[C@@H]3C[C@H]2CN3)c1)c1ccc2OCOc2c1 |r|
Structure:
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